5 ESSENTIAL ELEMENTS FOR PUFFLA

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4.4 Specific warnings and safeguards to be used Tolerance and Opioid Use Disorder (abuse and dependence) Tolerance, Actual physical and psychological dependence, and opioid use disorder (OUD) might develop upon recurring administration of opioids. Abuse or intentional misuse of opioids may well lead to overdose and/or Dying. The chance of developin